Description
METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).
METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN helps to treat neuropathic pain.
Take METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN as prescribed. Based on your medical condition, your doctor will decide the dose and duration. In some cases, METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. The majority of these side effects do not necessitate medical attention and will subside gradually over time. However, if you are experiencing these side effects regularly, you should consult your doctor.
Please do not take METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN if you are allergic to any of its ingredients. Consult your doctor before taking METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN if you are pregnant or breastfeeding. METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN may cause drowsiness and dizziness, so drive only if you are alert. METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.
Uses: Treatment of Neuropathic pain
Directions for Use: Swallow it as a whole with water; do not crush, break or chew it.
Storage: Store in a cool and dry place away from sunlight.
Side Effects:
- Constipation
- Dry mouth
- Headache
- Feeling sleepy, tired or dizzy
- Diarrhoea
In-Depth Precautions and Warning
Drug Warnings –
If you are allergic to any of the ingredients in METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN, do not consume it. Please do not stop taking METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN without first consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN unless your doctor has prescribed it. METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN may cause drowsiness and dizziness, therefore drive only if you are alert. METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.
Drug Interactions –
Drug-Drug Interactions: METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN may have interaction with antidepressant medications (e.g. duloxetine, sertraline, escitalopram), pain killer medications (e.g. codeine, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), anti-convulsant medications (e.g. topiramate), anti-anxiety medications (e.g. alprazolam), sedative-hypnotics medications (e.g. zolpidem), antihistamine medications (e.g. diphenhydramine, cetirizine), muscle relaxant medications (e.g. cyclobenzaprine), antiemetic medications (e.g. ondansetron), and herbal medications to treat depression (e.g. St John’s wort).
Drug-Food Interactions: Avoid alcohol consumption while taking METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN as it might cause increased drowsiness and sleepiness.
Drug-Disease Interactions: Use METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN with medical advice if you have had anticholinergic effects, cardiovascular disease, pheochromocytoma, acute myocardial infarction recovery, cardiovascular disease, depression, seizure disorders, drug dependence, suicidal tendency, angioedema, creatine kinase elevations, peripheral oedema, PR interval prolongation, bone marrow suppression, diabetes, renal/liver disease, schizophrenia/bipolar disorder, hyper/hypoglycemia, schizophrenia, thyroid disorders and urinary retention.
